NVP-BEZ235 (Dactolisib) Has Protective Effects in a Transgenic Mouse Model of Alzheimer’s Disease

Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1-42 induced neurotoxicity and memory impairment.

Alzheimer's Disease (AD) is a progressive neurodegenerative disease and the main cause of dementia. Substantial evidences indicate that there is over-activation of the PI3K/Akt/mTOR axis in AD. Therefore, the aim of the present study was to investigate the effects of NVP-BEZ235 (BEZ; dactolisib), a dual PI3K/mTOR inhibitor that is under phase I/II clinical trials for the treatment of some types...

Effects of hyperoxia in alzheimers transgenic mice

NVP-BEZ235 synergizes cisplatin sensitivity in osteosarcoma

Osteosarcoma(OS) remains a major health concern in childhood and adolescence, although cisplatin is one of the gold standard chemotherapeutic drugs in the treatment of OS, chemoresistant to cisplatin is common. Phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin inhibitor (mTOR) pathway and autophagy regulates chemosensitivity incancer cells. In this study, we hypothesized that N...

Quantification of Microtubule Stabilizing Drug Treatment effect on Axonal Transport Rate in a Transgenic Mouse Model of Alzheimers Disease

J. Kim, I-Y. Choi, M. L. Michaelis, and S-P. Lee Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, Neurology, University of Kansas Medical Center, Kansas City, KS, United States, Pharmacology & Toxicology, University of Kansas, Lawrence, KS, United States, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, U...

Cholinergic neuropathology in a mouse model of Alzheimer's disease

Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...